Sunday, November 4, 2012
Herbalith tiene Suplementos herbales para tratar el insomnio
Herbalith tiene Suplementos herbales para tratar el insomnio
Si necesita ayuda para dormir bien durante la noche, pero no desea tomar medicamentos, un suplemento herbal puede ser exactamente lo que busca. He aquí los hechos sobre las hierbas que se usan más comúnmente para inducir el sueño.
El insomnio es la incapacidad de dormir a una hora esperada. Las píldoras para dormir y los medicamentos para resfríos que causan somnolencia pueden brindar un alivio temporario, pero los efectos en última instancia disminuirán. En última instancia, podría ser necesario aumentar la dosis y podría producirse una dependencia al medicamento. Además, las píldoras para dormir pueden tener serios efectos secundarios.
Lúpulo
La planta de lúpulo (Humulus lupulus) se usa normalmente para dar sabor a la cerveza. Desde la antigüedad, las flores se usan para tratar el insomnio leve. Se dice que dormir sobre almohadas rellenas con flores de lúpulo induce al sueño. El lúpulo, combinado con la valeriana, produce una sedación suave. Se desconoce la dosis más eficaz. El lúpulo es relativamente seguro. Pero existen informes de exantemas alérgicos en la piel después de manipular la planta. No use lúpulo si sufre de depresión.
Pasionaria
La pasionaria (Passiflora incarnata L.) se usaba en la antigüedad y se usa hoy en día como sedante suave. En estudios con ratones, la pasionaria produjo sedación. No existe evidencia suficiente para recomendarla como tratamiento para el insomnio. Parece segura, aunque puede aumentar el efecto de otros medicamentos, especialmente los sedantes.
Valeriana
Durante siglos, los europeos usaron la valeriana como sedante y ayuda para dormir. La planta de valeriana tiene raíces gruesas con un olor desagradable. El extracto de valeriana se produce a partir de las raíces disecadas, y se usa actualmente para estimular la relajación y el sueño. Los estudios de investigación clínica han mostrado evidencia contradictoria en la eficacia de la valeriana para el insomnio. La valeriana parece segura, pero puede afectar la capacidad para conducir u operar maquinaria.
El insomnio a veces puede estar relacionado con otros problemas de salud. Si tiene episodios de insomnio frecuentes, severos o con empeoramiento, o si padece de insomnio desde hace tiempo, se recomienda tratarlo con su médico.
VitaVerde pastillas
Granos como el trigo y la cebada se consumen ordinariamente en su estado maduro; una vez que sus semillas han madurado completamente. Sin embargo, el uso de las formas verdes e inmaduras de estas plantas se ha defendido para fomentar la salud. El jugo de pasto de trigo es uno de estos "alimentos verdes." Se popularizó en la década de 1960 por Ann Wigmore. Ella afirmaba que el uso de jugo de pasto de trigo la había curado de la enfermedad colitis ulcerativa; además, cuando ella se lo dio a sus vecinos, su salud también mejoró. Ella continuó hasta convertirse en una importante figura en el movimiento de salud natural.
Desde el pasto de trigo, una sucesión de "bebidas verdes" se ha vuelto popular para "limpiar al cuerpo" y mejorar la salud en general. El "magma de cebada" y alga azul-verde se encuentran dentro de esta tradición.
No se cuestiona que el jugo de pasto de trigo sea un alimento nutritivo, que contenga numerosos aminoácidos, vitaminas y minerales. Sin embargo, además de conocidos nutrientes humanos, el pasto de trigo también contiene otras numerosas sustancias que los partidarios afirman que proporcionan beneficio.
Por ejemplo, el pasto de trigo, como todos los productos de plantas frondosas, contiene clorofila, la sustancia usada por las plantas para crear glucosa a partir de dióxido de carbono y energía de luz. La clorofila purificada químicamente se volvió un popular suplemento alimenticio para la salud en la década de 1960, cuando se promovió como una cura para muchas enfermedades. El papel central de la clorofila en el metabolismo de las plantas de alguna manera se creía que sugería beneficio para las personas. Sin embargo, los animales no tienen más que un uso obvio de la clorofila del que las plantas tienen de la hemoglobina (la sustancia vital en los glóbulos rojos). Ciertamente es posible que la clorofila pueda, por accidente químico, ofrecer beneficio para animales, pero no hay evidencia significativa para indicar que en realidad lo haga.
además de aumentar su consumo de probióticos, usted puede tomar suplementos de fructooligosacáridos , que pueden promover que las colonias de bacteria de ayuda florezcan en el tracto digestivo. (Los fructooligosacáridos son carbohidratos que se encuentran en la fruta. Fructo significa "fruta," y un oligosacárido es un tipo de carbohidrato.) Tomar este suplementos es como poner abono en el jardín; está pensado para fomentar un ambiente saludable para la bacteria que quiere tener dentro de usted. La dosis diaria típica de frutooligosacáridos es entre 2 y 8 g.
Tambien tiene probioticos
Evidencia de muchos pero no de todos los ensayos doble ciego controlados por placebo sugiere que los probióticos pueden ser útiles para muchos tipos de diarrea así como también para el síndrome del intestino irritable. Además, los probióticos han demostrado promesas importantes para prevenir o tratar eleccema, previniendo las infecciones vaginales por cándida, tratando la colitis ulcerativa, y ayudando a prevenir los resfriados, posiblemente al mejorar la inmunidad.
La bacteria Helicobacter pylori es la causa principal de las úlceras en el estómago y el duodeno. Los antibióticos pueden matar la H. pylori, pero se debe usar más de uno al mismo tiempo y aún así la bacteria no necesariamente es erradicada. Los probióticos pueden ser útiles. La evidencia sugiere que varios probióticos puede inhibir el crecimiento de la H. pylori. Mientras este efecto no parece ser lo suficientemente fuerte para que el tratamiento probiótico erradique a la H. pylori por su cuenta, pruebas preliminares, incluyendo un prueba doble ciego, sugiere que varios probióticos pueden ayudar a estandarizar que la terapia probiótica funcione mejor, mejorando la tasa de erradicación y reduciendo los efectos secundarios. Pruebas doble ciego preliminares sugieren que los probióticos pueden ayudar a prevenir enfermedades cardíacas reduciendo los niveles de colesterol. El tratamiento probiótico también ha sido propuesto como tratamiento para las aftas dolorosas y como una medida contra el cancer de colón, pero no existe evidencia sólida de que se efectivo. Tambien tiene Digestive Enzymes apoya el proceso de reponer los niveles de enzimas en el cuerpo. Esto ayuda a aliviar la excesiva carga del páncreas. Cada cápsula proporciona enzimas microbianas de origen vegetal diseñadas para ayudar a la digestión de una manera óptima
.
La bacteria Helicobacter pylori es la causa principal de las úlceras en el estómago y el duodeno. Los antibióticos pueden matar la H. pylori, pero se debe usar más de uno al mismo tiempo y aún así la bacteria no necesariamente es erradicada. Los probióticos pueden ser útiles. La evidencia sugiere que varios probióticos puede inhibir el crecimiento de la H. pylori. Mientras este efecto no parece ser lo suficientemente fuerte para que el tratamiento probiótico erradique a la H. pylori por su cuenta, pruebas preliminares, incluyendo un prueba doble ciego, sugiere que varios probióticos pueden ayudar a estandarizar que la terapia probiótica funcione mejor, mejorando la tasa de erradicación y reduciendo los efectos secundarios. Pruebas doble ciego preliminares sugieren que los probióticos pueden ayudar a prevenir enfermedades cardíacas reduciendo los niveles de colesterol. El tratamiento probiótico también ha sido propuesto como tratamiento para las aftas dolorosas y como una medida contra el cancer de colón, pero no existe evidencia sólida de que se efectivo. Tambien tiene Digestive Enzymes apoya el proceso de reponer los niveles de enzimas en el cuerpo. Esto ayuda a aliviar la excesiva carga del páncreas. Cada cápsula proporciona enzimas microbianas de origen vegetal diseñadas para ayudar a la digestión de una manera óptima
.
El aceite de pescado y Coenzima Q 10
El aceite de pescado contiene ácidos omega-3, uno de los dos principales tipos de ácidos grasos esenciales. (Los Ácidos grasos omega-6 son el otro tipo principal.) Los ácidos grasos esenciales son grasas especiales que el cuerpo necesita tanto como necesita de las vitaminas.
La mayor parte de la investigación sobre los beneficios potenciales de los ácidos omega-3 comenzó cuando estudios en personas Inuit (Eskimales) descubrieron que aunque sus dietas contenían una enorme cantidad de grasa de pescado, focas y ballenas, ellos rara vez sufrían de ataques cardíacos. Esto es supuestamente debido a que sus fuentes de grasa son altas en ácidos grasos omega-3.
Investigaciones posteriores descubrieron que los ácidos grasos omega-3 encontrados en el aceite de pescado pueden disminuir los niveles de triglicéridos en la sangre, "adelgazar" la sangre, así como disminuir la inflamación en varias partes del cuerpo. Estos efectos, así como otros, podrían explicar muchos de los aparentes beneficios del aceite de pescado.
Coenzima Q 10 (CoQ 10 ), también conocida como ubiquinona, es un poderoso antioxidante descubierto por los investigadores en la University of Wisconsin en 1957. El nombre de este suplemento viene de la palabra ubicuo, que significa "que se encuentra en todas partes". Además, la CoQ 10 se encuentra en todas las células del cuerpo. Desempeña un papel básico en la mitocondria, las partes de la célula que producen energía a partir de la glucosa y de los ácidos grasos.
Los científicos japoneses fueron los primeros en descubrir las propiedades terapéuticas de la CoQ 10 en la década de 1960. Actualmente, es ampliamente recetada en Europa, Israel y Japón para enfermedades cardiacas. La CoQ 10 parece ayudar al corazón durante las ocasiones de estrés sobre el músculo cardíaco, quizá al ayudarlo a utilizar su energía de manera más eficiente.
El mejor uso establecido de la CoQ 10 es para la insuficiencia cardíaca congestiva, pero la evidencia de que funciona no es completamente consistente. La investigación actual sugiere que también podría ser útil para otros tipos de problemas cardíacos, el mal de Parkinson y muchas otras enfermedades. Generalmente se utiliza como complemento de las terapias estándar, en vez de tratamiento primario.
La complementación de CoQ 10 también podría ser de valor para contrarrestar los efectos secundarios de ciertos medicamentos prescritos.
La dosis típica recomendada de CoQ 10 es de 30 a 300 mg al día, frecuentemente dividida en 2 a 3 dosis; se han utilizado dosis más grandes diarias en algunos estudios. La CoQ 10 es soluble en grasa y podría absorberse mejor cuando se toma en una forma de gel con base en aceite suave en vez de una forma seca tal como tabletas y cápsulas.
OCTOVITE Combatir Infecciones
Se necesita OCTOVITE para:
Ojos Saludables
Combatir Infecciones
Piel Saludable
Actualmente, el ginkgo es la hierba más extensamente recetada en Alemania, alcanzando una cuenta total de prescripción de más de 6 millones en 1995. Los médicos alemanes consideran que es tan efectiva como cualquier tratamiento de medicamentos para la enfermedad de Alzheimer y otras formas severas de deterioro de la memoria y de la función mental. Según algunos pero no todos los estudios, el ginkgo también puede ser útil para mejorar la memoria en ancianos con formas más leves de pérdida de memoria.Evidencia poco convincente insinúa que el ginkgo (solo o en combinación conginseng o vinpocetina) puede ser útil para mejorar la memoria en los jóvenes.
La Germany's Commission E también recomienda el ginkgo para el tratamiento de la circulación restringida en las piernas debido al endurecimiento de las arterias conocido como claudicación intermitente.
Ensayos clínicos preliminares doble ciego sugieren que el ginkgo también puede ser útil para elPMS, mal de las alturas, glaucoma, degeneración macular, vértigo, y pérdida repentina de la audición.
PriVita y estrona
Para Mujeres
Mecanismo de Acción de PriVita Inhibidor de la aromatasa no esteroideo potente y selectivo. Por inhibición de la aromatasa, la conversión de androstendiona en estrona y testosterona a estradiol, se impide. Anastrozol causa una disminución en los niveles de sulfato de estrona.
Para Hombres
Privita es muy singular, es una respuesta a un problema que se llama ginecomastia. Hombres Atención! Sus problemas masculinos no puede estar relacionado con la caída de los niveles de testosterona, pero el consumo de estrógeno, la hormona femenina principal. Usted está siendo inundado con hormonas femeninas en los alimentos, el aire y el agua que beber y bañarse pulg está dañando su sistema de manera que ni siquiera imaginado. Eso, naturalmente, en la parte superior de la caída de los niveles de hormonas masculinas, puede causar una condición llamada dominación del estrógeno.Tiene los mejores ingredientes para luchar contra la dominación del estrógeno y ayudar a todo, desde su vida sexual a su cuerpo con la próstata! No pierdas ni un día. Haz algo ahora para cambiar su vida y proteger la salud de este peligro nuevo y creciente, intente Privita.Una vez que usted comience a tomar Privita usted nunca necesitará otro refuerzo sexual.
Sunday, December 11, 2011
Options for Bioidentical Hormone Therapy and Wiley Protocol
FAQ on the Wiley Protocol
The USPTO has recognized the Wiley Protocol as unique with its recent patent ruling : The Wiley Protocol # 7,879,830.
Patented for treatment using a 28-day biomimetic, variable dose cycling bio-identical hormone therapy protocol, they can now be assured they are getting the real Protocol made by trained pharmacists and dispensed by knowledgeable physicians.
The Wiley Protocol also is the only menopausal HRT method developed which specifically address the phenomenon of receptor anticipation. This biological function assures that when the hormones are utilized they will be maximally effective and protective.
Receptor anticipation stipulates that one hormone will signal the cells to begin to prepare to receive a second hormone. Receptor anticipation is seen in the relationship between estradiol and progesterone. When estradiol surges at day 12 of a typical 28 day cycle it signals cells throughout the body to begin to produce progesterone receptors so that the cells can recognize and properly respond to the impending progesterone surge, which reaches a maximum at day 21. This process requires peaking levels of estradiol to work properly. Peaking surges of estradiol naturally occur in a menstrual cycle and is mirrored as well in the Wiley Protocol.
Q. What is the Wiley ProtocolTM?
A. The Wiley ProtocolTM, as described in the book Sex, Lies, and Menopause, by T. S. Wiley and Julie Taguchi, M.D., is a specific protocol of administering bio-mimmetic hormones to women for those seeking hormone replacement therapy (HRT). This protocol differs from conventional HRT in many ways: it uses only bio-identical estrogen (estradiol, specifically) and progesterone, made by Wiley-registered compounding pharmacies in cream form; the hormones are applied on the skin; the dosage for each day varies so as to attempt to duplicate the 28-day menstrual cycle of a youthful reproductive woman, including hitting peri-ovulation peak serum levels of estradiol and progesterone (in the luteal phase). The reasons for administering HRT in this specific manner are detailed in the book. The goal of attaining a youthful woman's hormone levels are based on widely known statistics that youthful women who have appropriate levels of hormones are the most protected from breast cancer, heart disease, as well as most diseases which eventually afflict women as they age and therefore lose their sex hormones. The book offers a detailed look at why women not only need HRT, but that they need it at youthful levels, from an evolutionary biological perspective. Ms. Wiley and Dr. Taguchi discuss the benefits of this protocol in the book, which include, but are not limited to, the achievement of G1 growth arrest in appropriate estrogen-receptive cells with peaking of estrogen to peri-ovulation ranges, and apoptosis (pre-programmed cell death) when progesterone peaks in the luteal phase (typically day 21 of a 28-day menstrual cycle). They argue that without regular G1 arrest and apoptosis, as intended to naturally occur with each menstrual cycle, diseases such as cancer are much more likely to occur. Ms. Wiley's method of HRT is the only one based on the priciniples of bio-physics and rhythm; hence she coined the Protocol “bio-mimmetic”.
The Wiley ProtocolTM largely differs from conventional HRT in its recommendation of using much larger doses of hormones in HRT, as well a re-instituting rhythm (not static dosing), since the aim is youthful levels of hormones. Traditional conventional methods have largely used very low doses without blood-monitoring, in flat-line, static doses. The Wiley ProtocolTM also utilizes large doses of progesterone transdermally (through the skin), whereas FDA-approved forms of natural progesterone are only available in oral or vaginal routes, based on absorption studies. Monitoring of hormone levels on this protocol are done with serum blood tests, which has not been concluded to be a valid way of measuring progesterone levels when it is applied through the skin. Many practitioners argue that saliva testing is more accurate specifically with regard to the application of progesterone topically through the skin, although this is currently controversial. It appears that levels of progesterone measured in the saliva vs. venipuncture appear to vary widely.
Based on the Women's Health Initiative (WHI) results published in 2002, conventional medical practitioners have recommended against routine HRT for preventing disease, and to only resort to HRT for the treatment of poorly-tolerated menopausal symptoms. In such cases, current conventional wisdom advises patients to use the lowest doses of HRT for the shortest amount of time necessary for control of symptoms. In addition, it has now become widespread practice for conventional practitioners to routinely prescribe anti-depressants and anti-seizure medications for the symptomatic relief of menopausal symptoms, despite the lack of symptoms of depression of seizure disorder! However, the results of the WHI do not apply to all women, and I advise all women to thoroughly review the results of the WHI with their physicians before making any final decisions. For a more detailed review of WHI results, please log on to www.imsociety.org, the website for the International Menopause Society (IMS), for an excellent critique of the WHI in their position statement presented by the IMS expert panel, revised in 2004, and again in 2007, with recent meeting updates from 2008.
The effects of this protocol have not been evaluated in any recognized clinical trials, although the BHOT (Bio-identical Hormones On Trial) study, which will also evaluate this protocol, is in its initial stages of data-gathering. The Wiley ProtocolTM is currently the only compounded bio-identical hormone regimen that is standardized in its dosage and preparation, via multiple Wiley-registered pharmacies, who have entered into contract with Ms. Wiley. Beyond that, the only results we have which speak to the effects of this protocol are largely anecdotal, mainly from the probable 10,000 women nation-wide who have been on this protocol for various lengths of time over the past 10 years. T. S. Wiley herself, as well as her close friends and family members, have reportedly been on this protocol for over 10 years, with very positive results.
Opinions, both positive and negative, regarding this protocol abound, and have recently received great attention in the lay press coverage and across the internet. However, the only consensus about this protocol put forth by a recognized medical organization thus far is summarized in the May 2005 conference of the American College for the Advancement of Medicine (ACAM), which can be reviewed at http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1193553.
Q. How is the Wiley ProtocolTM administered and what can I expect?
A. The protocol is administered either in the arms or the thighs, in a consistent manner so as to duplicate normal hormonal rhythm of a youthful woman, as verified by serial blood testing on specific days of the Protocol. Side effects are usually transient, and depend largely on a woman's hormone status prior to applying the protocol. For instance, a woman who is several years postmenopausal without HRT may require a longer period of adjustment to such youthful levels of hormones as compared to someone who is just entering menopause, whose body has been used to much higher levels of hormones up until recently. Predictable monthly 5-day menstrual bleeds are the rule on this protocol in women with intact uterus, although establishing such regularity may take up to 1-3 months depending on the woman's individual situation. Therefore, this is NOT the protocol for a patient with an intact uterus who no longer wishes to experience monthly bleeds! The Protocol calls for administration of full complement of progesterone along with estrogen, even in women who have had hysterectomies, which is another point of difference from conventional HRT. Detailed instructions on how to apply the hormones, potential drug interactions, and potential interfering factors such as exercise, are included on a pharmacy package insert with each batch of the creams. Common symptoms during the adjustment period as the body adapts to the Protocol include and are not limited to: headache, nausea, dizziness, fluid retention, and breast tenderness. Patients should thoroughly review the FAQ section of T. S. Wiley's official website at www.thewileyprotocol.com before actually initiating the protocol, as answers to commonly asked questions are reviewed.
Q. What if I want to try the Wiley ProtocolTM?
A. The decision to initiate HRT (which includes the Wiley ProtocolTM) or not is a very personal decision, and should be arrived at after thorough research of the literature and discussion with a knowledgeable physician regarding each individual's situation, including risk/benefit assessment based on genetics, risk factors, lifestyle, symptoms, and quality of life. Patients should also realize that the decision whether to initiate HRT need not be a permanent decision, and that repeat assessments at regular intervals regarding such a decision may actually be beneficial. As mentioned in the answer to the previous question, the Wiley ProtocolTM has garnered much attention in the lay press recently, both positive and negative. Those who are interested in initiating this protocol are advised to thoroughly peruse the May 2005 summary of the ACAM conference at http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1193553, which renders an opinion from a respectable medical organization. It is interesting to note that in the past few years, several prominent anti-aging experts are now acknowledging the importance of rhythm in HRT by adapting variations of the Wiley ProtocolTM, only at lower doses into their own practices, as per presentations at ACAM. Positive opinions can be found at T. S. Wiley's official website at www.thewileyprotocol.com, as well Suzanne Somers' personal testimonial in her new book, Ageless, as well as subsequent books over the past 3 years. Negative opinions can be found at http://www.nytimes.com/2006/10/15/fashion/15suzanne.html?_r=1&ref=health&oref=slogin, which discusses a letter sent by physicians Erika Schwarz, et al to the editors of Ageless, and can also be found on multiple websites using a Google search of "Wiley ProtocolTM".
Documentation regarding the effects of administering this protocol to women of all ages have been anecdotal thus far, and there appears to be wide variation in how women absorb the protocol transdermally, and multiple adjustments may need to be made over several months in order to arrive at blood levels of estradiol and progesterone as specified by Wiley in her book.
Once a woman has made the decision to initiate the Wiley ProtocolTM, the prescription will be filled at a Wiley-registered pharmacy, who has agreed to compound the bio-identical creams to Ms. Wiley's specifications. Wiley-registered pharmacies have also agreed to cap the monthly price of both hormones at a reasonable rate. Insurance coverage for this Protocol will vary according to individual insurance plans. Wiley registration also allows standardization of the hormone creams (the lack of standardization was the basis for Wyeth's--maker of Premarin--petition filed with FDA a few years ago to urge the FDA to closely examine the lack of regulation and standardization of compounded products offered by compounding pharmacies in general), which, more importantly, allows this Protocol to be studied scientifically, as in the BHOT trial that is ongoing.
Patients wishing to initiate the Wiley ProtocolTM should read the book before scheduling an in-person consultation with their provider to discuss the protocol in detail, including a detailed discussion of the controversy surrounding this protocol. By the third month of using the protocol, patients must have day 12 serum estradiol level checked, along with FSH and progesterone levels, and a day 21 serum estradiol and progesterone levels. These blood levels are helpful in assessing the peaking of both estradiol (day 12) and progesterone (day 21), and provide guidance in determining whether or not the Protocol needs to be adjusted for each individual, although most adjustments are symptom-based. Patients should have repeat appointments with their provider shortly after the results of these levels are available to discuss any fine-tuning which may need to be made based on their lab results as well as tolerability of and response to the protocol. If adjustments in the protocol have been made, then follow-up lab testing should be obtained in another three months. It is also a good idea for patients to have regular follow-up pelvic ultrasounds in those who still possess their uterus, so as to monitor closely for any potential side-effects, such as development of fibroids, or endometrial (uterine lining) thickening. This is especially important given that monitoring progesterone effects via serum testing is not always reliable, as stated above. This is a standard recommendation for any woman wishing to initiate any form of HRT and is not limited to those on the Wiley ProtocolTM.
Q. What is the difference between the Wiley Protocol and bio-identical hormones?
A. Wiley ProtocolTM uses bio-identical hormones applied to the skin, in a rhythmic pattern, trying to duplicate the youthful woman's menstrual cycle. All other forms of traditional bio-identical hormones have used them in static (without rhythm), low doses, copying prempro (the combination drug premarin plus provera, which was the drug studied in the Women's Health Initiative) as a template. For a more thorough explanation of the comparisons, as well as how the use of bio-identical hormones have evolved over the past several decades, please refer to www.thewileyprotocol.com.
Q. Is there a Wiley Protocol for men?
A. Yes, T. S. Wiley has created the Wiley Protocol for men. Here, the goal proposed is to duplicate the levels of testosterone as well as DHEA of a healthy, young man, using transdermal creams, dosed so as to provide normal rhythm. There has been less experience with this protocol compared to the Wiley Protocol for women, as it is fairly new. Specific levels of testosterone and DHEA are targeted for certain days of the man's cycle which are monitored with serial lab testing. As with the Wiley Protocol for women, patients who initiate the men's Protocol will be required to have baseline testing and evaluation before being prescribed the Protocol, followed by proper follow-up testing and appointments similar to women.
Some of this information is adapted from http://balancedapproaches.com/people/ching/faq/wiley.html
The USPTO has recognized the Wiley Protocol as unique with its recent patent ruling : The Wiley Protocol # 7,879,830.
Patented for treatment using a 28-day biomimetic, variable dose cycling bio-identical hormone therapy protocol, they can now be assured they are getting the real Protocol made by trained pharmacists and dispensed by knowledgeable physicians.
The Wiley Protocol also is the only menopausal HRT method developed which specifically address the phenomenon of receptor anticipation. This biological function assures that when the hormones are utilized they will be maximally effective and protective.
Receptor anticipation stipulates that one hormone will signal the cells to begin to prepare to receive a second hormone. Receptor anticipation is seen in the relationship between estradiol and progesterone. When estradiol surges at day 12 of a typical 28 day cycle it signals cells throughout the body to begin to produce progesterone receptors so that the cells can recognize and properly respond to the impending progesterone surge, which reaches a maximum at day 21. This process requires peaking levels of estradiol to work properly. Peaking surges of estradiol naturally occur in a menstrual cycle and is mirrored as well in the Wiley Protocol.
Q. What is the Wiley ProtocolTM?
A. The Wiley ProtocolTM, as described in the book Sex, Lies, and Menopause, by T. S. Wiley and Julie Taguchi, M.D., is a specific protocol of administering bio-mimmetic hormones to women for those seeking hormone replacement therapy (HRT). This protocol differs from conventional HRT in many ways: it uses only bio-identical estrogen (estradiol, specifically) and progesterone, made by Wiley-registered compounding pharmacies in cream form; the hormones are applied on the skin; the dosage for each day varies so as to attempt to duplicate the 28-day menstrual cycle of a youthful reproductive woman, including hitting peri-ovulation peak serum levels of estradiol and progesterone (in the luteal phase). The reasons for administering HRT in this specific manner are detailed in the book. The goal of attaining a youthful woman's hormone levels are based on widely known statistics that youthful women who have appropriate levels of hormones are the most protected from breast cancer, heart disease, as well as most diseases which eventually afflict women as they age and therefore lose their sex hormones. The book offers a detailed look at why women not only need HRT, but that they need it at youthful levels, from an evolutionary biological perspective. Ms. Wiley and Dr. Taguchi discuss the benefits of this protocol in the book, which include, but are not limited to, the achievement of G1 growth arrest in appropriate estrogen-receptive cells with peaking of estrogen to peri-ovulation ranges, and apoptosis (pre-programmed cell death) when progesterone peaks in the luteal phase (typically day 21 of a 28-day menstrual cycle). They argue that without regular G1 arrest and apoptosis, as intended to naturally occur with each menstrual cycle, diseases such as cancer are much more likely to occur. Ms. Wiley's method of HRT is the only one based on the priciniples of bio-physics and rhythm; hence she coined the Protocol “bio-mimmetic”.
The Wiley ProtocolTM largely differs from conventional HRT in its recommendation of using much larger doses of hormones in HRT, as well a re-instituting rhythm (not static dosing), since the aim is youthful levels of hormones. Traditional conventional methods have largely used very low doses without blood-monitoring, in flat-line, static doses. The Wiley ProtocolTM also utilizes large doses of progesterone transdermally (through the skin), whereas FDA-approved forms of natural progesterone are only available in oral or vaginal routes, based on absorption studies. Monitoring of hormone levels on this protocol are done with serum blood tests, which has not been concluded to be a valid way of measuring progesterone levels when it is applied through the skin. Many practitioners argue that saliva testing is more accurate specifically with regard to the application of progesterone topically through the skin, although this is currently controversial. It appears that levels of progesterone measured in the saliva vs. venipuncture appear to vary widely.
Based on the Women's Health Initiative (WHI) results published in 2002, conventional medical practitioners have recommended against routine HRT for preventing disease, and to only resort to HRT for the treatment of poorly-tolerated menopausal symptoms. In such cases, current conventional wisdom advises patients to use the lowest doses of HRT for the shortest amount of time necessary for control of symptoms. In addition, it has now become widespread practice for conventional practitioners to routinely prescribe anti-depressants and anti-seizure medications for the symptomatic relief of menopausal symptoms, despite the lack of symptoms of depression of seizure disorder! However, the results of the WHI do not apply to all women, and I advise all women to thoroughly review the results of the WHI with their physicians before making any final decisions. For a more detailed review of WHI results, please log on to www.imsociety.org, the website for the International Menopause Society (IMS), for an excellent critique of the WHI in their position statement presented by the IMS expert panel, revised in 2004, and again in 2007, with recent meeting updates from 2008.
The effects of this protocol have not been evaluated in any recognized clinical trials, although the BHOT (Bio-identical Hormones On Trial) study, which will also evaluate this protocol, is in its initial stages of data-gathering. The Wiley ProtocolTM is currently the only compounded bio-identical hormone regimen that is standardized in its dosage and preparation, via multiple Wiley-registered pharmacies, who have entered into contract with Ms. Wiley. Beyond that, the only results we have which speak to the effects of this protocol are largely anecdotal, mainly from the probable 10,000 women nation-wide who have been on this protocol for various lengths of time over the past 10 years. T. S. Wiley herself, as well as her close friends and family members, have reportedly been on this protocol for over 10 years, with very positive results.
Opinions, both positive and negative, regarding this protocol abound, and have recently received great attention in the lay press coverage and across the internet. However, the only consensus about this protocol put forth by a recognized medical organization thus far is summarized in the May 2005 conference of the American College for the Advancement of Medicine (ACAM), which can be reviewed at http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1193553.
Q. How is the Wiley ProtocolTM administered and what can I expect?
A. The protocol is administered either in the arms or the thighs, in a consistent manner so as to duplicate normal hormonal rhythm of a youthful woman, as verified by serial blood testing on specific days of the Protocol. Side effects are usually transient, and depend largely on a woman's hormone status prior to applying the protocol. For instance, a woman who is several years postmenopausal without HRT may require a longer period of adjustment to such youthful levels of hormones as compared to someone who is just entering menopause, whose body has been used to much higher levels of hormones up until recently. Predictable monthly 5-day menstrual bleeds are the rule on this protocol in women with intact uterus, although establishing such regularity may take up to 1-3 months depending on the woman's individual situation. Therefore, this is NOT the protocol for a patient with an intact uterus who no longer wishes to experience monthly bleeds! The Protocol calls for administration of full complement of progesterone along with estrogen, even in women who have had hysterectomies, which is another point of difference from conventional HRT. Detailed instructions on how to apply the hormones, potential drug interactions, and potential interfering factors such as exercise, are included on a pharmacy package insert with each batch of the creams. Common symptoms during the adjustment period as the body adapts to the Protocol include and are not limited to: headache, nausea, dizziness, fluid retention, and breast tenderness. Patients should thoroughly review the FAQ section of T. S. Wiley's official website at www.thewileyprotocol.com before actually initiating the protocol, as answers to commonly asked questions are reviewed.
Q. What if I want to try the Wiley ProtocolTM?
A. The decision to initiate HRT (which includes the Wiley ProtocolTM) or not is a very personal decision, and should be arrived at after thorough research of the literature and discussion with a knowledgeable physician regarding each individual's situation, including risk/benefit assessment based on genetics, risk factors, lifestyle, symptoms, and quality of life. Patients should also realize that the decision whether to initiate HRT need not be a permanent decision, and that repeat assessments at regular intervals regarding such a decision may actually be beneficial. As mentioned in the answer to the previous question, the Wiley ProtocolTM has garnered much attention in the lay press recently, both positive and negative. Those who are interested in initiating this protocol are advised to thoroughly peruse the May 2005 summary of the ACAM conference at http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1193553, which renders an opinion from a respectable medical organization. It is interesting to note that in the past few years, several prominent anti-aging experts are now acknowledging the importance of rhythm in HRT by adapting variations of the Wiley ProtocolTM, only at lower doses into their own practices, as per presentations at ACAM. Positive opinions can be found at T. S. Wiley's official website at www.thewileyprotocol.com, as well Suzanne Somers' personal testimonial in her new book, Ageless, as well as subsequent books over the past 3 years. Negative opinions can be found at http://www.nytimes.com/2006/10/15/fashion/15suzanne.html?_r=1&ref=health&oref=slogin, which discusses a letter sent by physicians Erika Schwarz, et al to the editors of Ageless, and can also be found on multiple websites using a Google search of "Wiley ProtocolTM".
Documentation regarding the effects of administering this protocol to women of all ages have been anecdotal thus far, and there appears to be wide variation in how women absorb the protocol transdermally, and multiple adjustments may need to be made over several months in order to arrive at blood levels of estradiol and progesterone as specified by Wiley in her book.
Once a woman has made the decision to initiate the Wiley ProtocolTM, the prescription will be filled at a Wiley-registered pharmacy, who has agreed to compound the bio-identical creams to Ms. Wiley's specifications. Wiley-registered pharmacies have also agreed to cap the monthly price of both hormones at a reasonable rate. Insurance coverage for this Protocol will vary according to individual insurance plans. Wiley registration also allows standardization of the hormone creams (the lack of standardization was the basis for Wyeth's--maker of Premarin--petition filed with FDA a few years ago to urge the FDA to closely examine the lack of regulation and standardization of compounded products offered by compounding pharmacies in general), which, more importantly, allows this Protocol to be studied scientifically, as in the BHOT trial that is ongoing.
Patients wishing to initiate the Wiley ProtocolTM should read the book before scheduling an in-person consultation with their provider to discuss the protocol in detail, including a detailed discussion of the controversy surrounding this protocol. By the third month of using the protocol, patients must have day 12 serum estradiol level checked, along with FSH and progesterone levels, and a day 21 serum estradiol and progesterone levels. These blood levels are helpful in assessing the peaking of both estradiol (day 12) and progesterone (day 21), and provide guidance in determining whether or not the Protocol needs to be adjusted for each individual, although most adjustments are symptom-based. Patients should have repeat appointments with their provider shortly after the results of these levels are available to discuss any fine-tuning which may need to be made based on their lab results as well as tolerability of and response to the protocol. If adjustments in the protocol have been made, then follow-up lab testing should be obtained in another three months. It is also a good idea for patients to have regular follow-up pelvic ultrasounds in those who still possess their uterus, so as to monitor closely for any potential side-effects, such as development of fibroids, or endometrial (uterine lining) thickening. This is especially important given that monitoring progesterone effects via serum testing is not always reliable, as stated above. This is a standard recommendation for any woman wishing to initiate any form of HRT and is not limited to those on the Wiley ProtocolTM.
Q. What is the difference between the Wiley Protocol and bio-identical hormones?
A. Wiley ProtocolTM uses bio-identical hormones applied to the skin, in a rhythmic pattern, trying to duplicate the youthful woman's menstrual cycle. All other forms of traditional bio-identical hormones have used them in static (without rhythm), low doses, copying prempro (the combination drug premarin plus provera, which was the drug studied in the Women's Health Initiative) as a template. For a more thorough explanation of the comparisons, as well as how the use of bio-identical hormones have evolved over the past several decades, please refer to www.thewileyprotocol.com.
Q. Is there a Wiley Protocol for men?
A. Yes, T. S. Wiley has created the Wiley Protocol for men. Here, the goal proposed is to duplicate the levels of testosterone as well as DHEA of a healthy, young man, using transdermal creams, dosed so as to provide normal rhythm. There has been less experience with this protocol compared to the Wiley Protocol for women, as it is fairly new. Specific levels of testosterone and DHEA are targeted for certain days of the man's cycle which are monitored with serial lab testing. As with the Wiley Protocol for women, patients who initiate the men's Protocol will be required to have baseline testing and evaluation before being prescribed the Protocol, followed by proper follow-up testing and appointments similar to women.
Some of this information is adapted from http://balancedapproaches.com/people/ching/faq/wiley.html
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